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TargetIndoleamine 2,3-dioxygenase 1
LigandBDBM50126144
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1550107
IC50 38±n/a nM
Citation Peng YHUeng SHTseng CTHung MSSong JSWu JSLiao FYFan YSWu MHHsiao WCHsueh CCLin SYCheng CYTu CHLee LCCheng MFShia KSShih CWu SY Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1. J Med Chem 59:282-93 (2016) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Indoleamine 2,3-dioxygenase 1
Name:Indoleamine 2,3-dioxygenase
Synonyms:IDO | IDO-1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine-pyrrole 2,3-dioxygenase
Type:Enzyme
Mol. Mass.:45330.80
Organism:Homo sapiens (Human)
Description:n/a
Residue:403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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  Blast E-value cutoff:
BDBM50126144
n/a
NameBDBM50126144
Synonyms:CHEMBL3629569 | US10155972, Compound NewLink 1 | US10233190, Example 1304
TypeSmall organic molecule
Emp. Form.C18H22N2O
Mol. Mass.282.3801
SMILESOC(CC1c2ccccc2-c2cncn12)C1CCCCC1
Structure
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