| Reaction Details |
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 | Report a problem with these data |
| Target | Indoleamine 2,3-dioxygenase 1 |
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| Ligand | BDBM50138822 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1550107 (CHEMBL3756249) |
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| IC50 | 1139±n/a nM |
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| Citation |  Peng, YH; Ueng, SH; Tseng, CT; Hung, MS; Song, JS; Wu, JS; Liao, FY; Fan, YS; Wu, MH; Hsiao, WC; Hsueh, CC; Lin, SY; Cheng, CY; Tu, CH; Lee, LC; Cheng, MF; Shia, KS; Shih, C; Wu, SY Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1. J Med Chem59:282-93 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Indoleamine 2,3-dioxygenase 1 |
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| Name: | Indoleamine 2,3-dioxygenase 1 |
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| Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 45330.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14902 |
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| Residue: | 403 |
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| Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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| BDBM50138822 |
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| n/a |
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| Name | BDBM50138822 |
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| Synonyms: | CHEMBL3753777 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H23N3O |
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| Mol. Mass. | 297.3947 |
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| SMILES | OC(CC1Nc2ccccc2-c2cncn12)C1CCCCC1 |
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| Structure | 
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