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TargetAdenosine receptor A2a
LigandBDBM50139798
Substrate/Competitorn/a
Meas. Tech.ChEBML_1553861
Ki 6.7±n/a nM
Citation Zhou GAslanian RGallo GKhan TKuang RPurakkattle BDe Ruiz MStamford ATing PWu HWang HXiao DYu TZhang YMullins DHodgson R Discovery of aminoquinazoline derivatives as human A(2A) adenosine receptor antagonists. Bioorg Med Chem Lett 26:1348-54 (2016) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Adenosine receptor A2a
Name:Adenosine receptor A2a
Synonyms:A2A adenosine receptor (hA2A) | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:44716.46
Organism:Homo sapiens (Human)
Description:P29274
Residue:412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI
PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR
AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF
NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG
LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG
YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50139798
n/a
NameBDBM50139798
Synonyms:CHEMBL3763766 | US10138212, Example 88
TypeSmall organic molecule
Emp. Form.C20H16FN5O
Mol. Mass.361.3723
SMILESC[C@@H](NC(=O)c1nc(N)nc2c(F)cccc12)c1cccc2cccnc12 |r|
Structure
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