| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A2a |
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| Ligand | BDBM50139837 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1553861 |
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| Ki | 4.8±n/a nM |
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| Citation |  Zhou, G; Aslanian, R; Gallo, G; Khan, T; Kuang, R; Purakkattle, B; De Ruiz, M; Stamford, A; Ting, P; Wu, H; Wang, H; Xiao, D; Yu, T; Zhang, Y; Mullins, D; Hodgson, R Discovery of aminoquinazoline derivatives as human A(2A) adenosine receptor antagonists. Bioorg Med Chem Lett26:1348-54 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A2a |
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| Name: | Adenosine receptor A2a |
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| Synonyms: | A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44716.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29274 |
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| Residue: | 412 |
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| Sequence: | MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI
PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR
AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF
NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG
LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG
YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
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| BDBM50139837 |
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| n/a |
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| Name | BDBM50139837 |
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| Synonyms: | CHEMBL3764598 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H32FN7O4 |
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| Mol. Mass. | 609.6501 |
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| SMILES | COCCOc1ccc(cc1)N1CCN(CC1)C(=O)c1cnc2c(CNC(=O)c3nc(N)nc4c(F)cccc34)cccc2c1 |
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| Structure | 
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