Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetSolute carrier family 22 member 8
LigandBDBM50265079
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1552528 (CHEMBL3762006)
IC50 18000±n/a nM
Citation Ruminski, PGMassa, MStrohbach, JHanau, CESchmidt, MScholten, JAFletcher, TRHamper, BCCarroll, JNShieh, HSCaspers, NCollins, BGrapperhaus, MPalmquist, KECollins, JBaldus, JEHitchcock, JKleine, HPRogers, MDMcDonald, JMunie, GEMessing, DMPortolan, SWhiteley, LOSunyer, TSchnute, ME Discovery of N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis. J Med Chem59:313-27 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Solute carrier family 22 member 8
Name:Solute carrier family 22 member 8
Synonyms:OAT3 | Organic anion transporter 3 | S22A8_HUMAN | SLC22A8 | hOAT3
Type:PROTEIN
Mol. Mass.:59870.13
Organism:Homo sapiens (Human)
Description:ChEMBL_1486920
Residue:542
Sequence:
MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPW
VLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNK
LKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFR
FLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQL
TVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLN
LQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQI
IFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKG
CLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGI
TALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLG
SS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50265079
n/a
NameBDBM50265079
Synonyms:(4-[1-methyl-2,4-dioxo-6-(3-phenyl-prop-1-ynyl)-1,4-dihydro-2H-quinazolin-3-ylmethyl]-benzoic acid) | 4-((1-methyl-2,4-dioxo-6-(3-phenylprop-1-ynyl)-1,2-dihydroquinazolin-3(4H)-yl)methyl)benzoic acid | 4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID | CHEMBL496942 | MMP Inhibitor, 5
TypeSmall organic molecule
Emp. Form.C26H20N2O4
Mol. Mass.424.448
SMILESCn1c2ccc(cc2c(=O)n(Cc2ccc(cc2)C(O)=O)c1=O)C#CCc1ccccc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: