| Reaction Details |
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 | Report a problem with these data |
| Target | Solute carrier family 22 member 8 |
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| Ligand | BDBM50234348 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1552528 (CHEMBL3762006) |
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| IC50 | 59000±n/a nM |
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| Citation |  Ruminski, PG; Massa, M; Strohbach, J; Hanau, CE; Schmidt, M; Scholten, JA; Fletcher, TR; Hamper, BC; Carroll, JN; Shieh, HS; Caspers, N; Collins, B; Grapperhaus, M; Palmquist, KE; Collins, J; Baldus, JE; Hitchcock, J; Kleine, HP; Rogers, MD; McDonald, J; Munie, GE; Messing, DM; Portolan, S; Whiteley, LO; Sunyer, T; Schnute, ME Discovery of N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis. J Med Chem59:313-27 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Solute carrier family 22 member 8 |
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| Name: | Solute carrier family 22 member 8 |
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| Synonyms: | OAT3 | Organic anion transporter 3 | S22A8_HUMAN | SLC22A8 | hOAT3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59870.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1486920 |
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| Residue: | 542 |
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| Sequence: | MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPW
VLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNK
LKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFR
FLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQL
TVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLN
LQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQI
IFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKG
CLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGI
TALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLG
SS
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| BDBM50234348 |
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| n/a |
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| Name | BDBM50234348 |
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| Synonyms: | 4-((6-(4-methoxybenzylcarbamoyl)-4-oxopyrido[3,4-d]pyrimidin-3(4H)-yl)methyl)benzoic acid | 4-[6-(4-methoxy-benzylcarbamoyl)-4-oxo-pyrido[3,4-d]pyrimidin-3-ylmethyl]-benzoic acid | CHEMBL270050 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H20N4O5 |
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| Mol. Mass. | 444.4394 |
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| SMILES | COc1ccc(CNC(=O)c2cc3c(cn2)ncn(Cc2ccc(cc2)C(O)=O)c3=O)cc1 |
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| Structure | 
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