Reaction Details |
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Target | Trypanothione reductase |
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Ligand | BDBM50142683 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1552581 (CHEMBL3762226) |
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IC50 | 69200±n/a nM |
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Citation | Marcu, A; Schurigt, U; Müller, K; Moll, H; Krauth-Siegel, RL; Prinz, H Inhibitory effect of phenothiazine- and phenoxazine-derived chloroacetamides on Leishmania major growth and Trypanosoma brucei trypanothione reductase. Eur J Med Chem108:436-43 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Trypanothione reductase |
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Name: | Trypanothione reductase |
Synonyms: | N(1),N(8)-bis(glutathionyl)spermidine reductase | TPR | TR | TYTR_TRYBB | Trypanothione Reductase (TryR) |
Type: | Homodimer; oxidoreductase |
Mol. Mass.: | 53285.53 |
Organism: | Trypanosoma brucei brucei |
Description: | n/a |
Residue: | 492 |
Sequence: | MSKIFDLVVIGAGSGGLEAGWNAATLYKKRVAVIDVQTHHGPPHYAALGGTCVNVGCVPK
KLMVTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGL
DFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMPAIPGVEHCISSNE
AFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREEVTK
QLTANGIEIMTNENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQLGNVG
VKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVDTVFGNKPRKTDHT
RVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGSKYKKFVAKIVTNHS
DGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYLK
GEKMETLPESSL
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BDBM50142683 |
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n/a |
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Name | BDBM50142683 |
Synonyms: | CHEMBL1801896 |
Type | Small organic molecule |
Emp. Form. | C12H8ClNO |
Mol. Mass. | 217.651 |
SMILES | Clc1ccc2Oc3ccccc3Nc2c1 |
Structure |
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