| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50143215 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1553010 (CHEMBL3760294) |
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| IC50 | 9300±n/a nM |
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| Citation |  Kachhadia, V; Rajagopal, S; Ponpandian, T; Vignesh, R; Anandhan, K; Prabhu, D; Rajendran, P; Nidhyanandan, S; Roy, AM; Ahamed, FA; Surendran, N; Rajagopal, S; Narayanan, S; Gopalan, B Orally available stilbene derivatives as potent HDAC inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts. Eur J Med Chem108:274-86 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50143215 |
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| n/a |
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| Name | BDBM50143215 |
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| Synonyms: | CHEMBL3758457 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21FN2O2 |
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| Mol. Mass. | 352.402 |
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| SMILES | ONC(=O)\C=C\c1ccc(\C=C(\CNC2CC2)c2ccc(F)cc2)cc1 |
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| Structure | 
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