| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 1 |
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| Ligand | BDBM50143813 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1551183 |
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| Ki | 4.9±n/a nM |
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| Citation |  Yaseen R; Ekinci D; Senturk M; Hameed AD; Ovais S; Rathore P; Samim M; Javed K; Supuran CT Pyridazinone substituted benzenesulfonamides as potent carbonic anhydrase inhibitors. Bioorg Med Chem Lett 26:1337-41 (2016) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 1 |
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| Name: | Carbonic anhydrase |
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| Synonyms: | CA-I | CAB | Carbonate dehydratase I | Carbonic anhydrase 1 (CA I) | Carbonic anhydrase 1 (CA-I) | Carbonic anhydrase 1 (Recombinant CA I) | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase B | Carbonic anhydrase I (CA I) | Carbonic anhydrase I (CA-I) | Carbonic anhydrase I (CAI) | Carbonic anhydrase I (hCA I) | Carbonic anhydrase isoenzyme I (hCA I) | hCA |
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| Type: | Enzyme |
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| Mol. Mass.: | 28873.37 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00915 |
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| Residue: | 261 |
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| Sequence: | MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEI
INVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELH
VAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNF
DPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAV
PMQHNNRPTQPLKGRTVRASF
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| BDBM50143813 |
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| n/a |
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| Name | BDBM50143813 |
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| Synonyms: | CHEMBL3759894 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23N3O3S |
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| Mol. Mass. | 409.501 |
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| SMILES | NS(=O)(=O)c1ccc(cc1)-n1nc(ccc1=O)-c1ccc(cc1)C1CCCCC1 |
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| Structure | 
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