| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 12 |
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| Ligand | BDBM16417 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1551383 (CHEMBL3762504) |
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| Ki | 4.3±n/a nM |
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| Citation |  Carradori, S; Secci, D; De Monte, C; Mollica, A; Ceruso, M; Akdemir, A; Sobolev, AP; Codispoti, R; De Cosmi, F; Guglielmi, P; Supuran, CT A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms. Bioorg Med Chem24:1095-105 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 12 |
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| Name: | Carbonic anhydrase 12 |
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| Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 39456.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Catalytic domain of human cloned isozyme was used in the assay |
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| Residue: | 354 |
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| Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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| BDBM16417 |
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| n/a |
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| Name | BDBM16417 |
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| Synonyms: | (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetic acid | 2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)acetic acid | N-Phthaloylglycine | N-Phthalylglycine |
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| Type | Small organic molecule |
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| Emp. Form. | C10H7NO4 |
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| Mol. Mass. | 205.1669 |
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| SMILES | OC(=O)CN1C(=O)c2ccccc2C1=O |
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| Structure | 
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