| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
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| Ligand | BDBM50334352 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1551385 (CHEMBL3762506) |
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| Ki | 226±n/a nM |
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| Citation |  Lomelino, CL; Mahon, BP; McKenna, R; Carta, F; Supuran, CT Kinetic and X-ray crystallographic investigations on carbonic anhydrase isoforms I, II, IX and XII of a thioureido analog of SLC-0111. Bioorg Med Chem24:976-81 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 2 |
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| Name: | Carbonic anhydrase 2 |
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| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
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| Type: | Enzyme |
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| Mol. Mass.: | 29250.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00918 |
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| Residue: | 260 |
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| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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| BDBM50334352 |
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| n/a |
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| Name | BDBM50334352 |
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| Synonyms: | 4-(3-cyclopentylureido)benzenesulfonamide | 4-[(cyclopentylcarbamoyl)amino]benzenesulfonamide | CHEMBL1615215 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H17N3O3S |
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| Mol. Mass. | 283.347 |
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| SMILES | NS(=O)(=O)c1ccc(NC(=O)NC2CCCC2)cc1 |
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| Structure | 
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