| Reaction Details |
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 | Report a problem with these data |
| Target | Palmitoleoyl-protein carboxylesterase NOTUM |
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| Ligand | BDBM50144549 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1551504 (CHEMBL3762925) |
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| EC50 | 20±n/a nM |
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| Citation |  Han, Q; Pabba, PK; Barbosa, J; Mabon, R; Healy, JP; Gardyan, MW; Terranova, KM; Brommage, R; Thompson, AY; Schmidt, JM; Wilson, AG; Xu, X; Tarver, JE; Carson, KG 4H-Thieno[3,2-c]chromene based inhibitors of Notum Pectinacetylesterase. Bioorg Med Chem Lett26:1184-7 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Palmitoleoyl-protein carboxylesterase NOTUM |
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| Name: | Palmitoleoyl-protein carboxylesterase NOTUM |
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| Synonyms: | NOTUM | NOTUM_HUMAN | Palmitoleoyl-protein carboxylesterase NOTUM | hNOTUM |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55706.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_116492 |
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| Residue: | 496 |
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| Sequence: | MGRGVRVLLLLSLLHCAGGSEGRKTWRRRGQQPPPPPRTEAAPAAGQPVESFPLDFTAVE
GNMDSFMAQVKSLAQSLYPCSAQQLNEDLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRW
LLFLEGGWYCFNRENCDSRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVFI
PYCSSDVWSGASSKSEKNEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAGGTGVLL
NVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHTDCVDTITCAPTEAIRRGIRYWNG
VVPERCRRQFQEGEEWNCFFGYKVYPTLRCPVFVVQWLFDEAQLTVDNVHLTGQPVQEGL
RLYIQNLGRELRHTLKDVPASFAPACLSHEIIIRSHWTDVQVKGTSLPRALHCWDRSLHD
SHKASKTPLKGCPVHLVDSCPWPHCNPSCPTVRDQFTGQEMNVAQFLMHMGFDMQTVAQP
QGLEPSELLGMLSNGS
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| BDBM50144549 |
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| n/a |
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| Name | BDBM50144549 |
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| Synonyms: | CHEMBL3758291 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H5F3O2S2 |
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| Mol. Mass. | 302.292 |
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| SMILES | OC(=O)c1cc2CSc3c(F)c(F)c(F)cc3-c2s1 |
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| Structure | 
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