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TargetHuman diphtheria toxin-like ADP-ribosyltransferase (ARTD2 or PARP2)
LigandBDBM50084621
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1553354
Ki 0.850000±n/a nM
Citation Wang BChu DFeng YShen YAoyagi-Scharber MPost LE Discovery and Characterization of (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-ribose) Polymerase-1/2 Inhibitor, as an Anticancer Agent. J Med Chem 59:335-57 (2016) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD2 or PARP2)
Name:PARP 1, 2 and 3
Synonyms:(ARTD2 or PARP2) | Poly [ADP-ribose] polymerase 2 | Poly [ADP-ribose] polymerase 2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (PARP2) | Poly [ADP-ribose] polymerase 3 (PARP3)
Type:Enyme
Mol. Mass.:66225.70
Organism:Homo sapiens (Human)
Description:Q9UGN5
Residue:583
Sequence:
MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKD
RTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLN
QTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKF
LDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQE
LIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALME
ACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQ
HYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDL
HNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLK
NTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGP
ASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
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  Blast E-value cutoff:
BDBM50084621
n/a
NameBDBM50084621
Synonyms:BMN 673 | TALAZOPARIB | Talazoparib
TypeSmall organic molecule
Emp. Form.C19H14F2N6O
Mol. Mass.380.3509
SMILESCn1ncnc1[C@@H]1[C@H](Nc2cc(F)cc3c2c1n[nH]c3=O)c1ccc(F)cc1 |r|
Structure
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