| Reaction Details |
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 | Report a problem with these data |
| Target | Indoleamine 2,3-dioxygenase 1 |
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| Ligand | BDBM50145162 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1553580 (CHEMBL3769112) |
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| EC50 | 212±n/a nM |
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| Citation |  Lin, SY; Yeh, TK; Kuo, CC; Song, JS; Cheng, MF; Liao, FY; Chao, MW; Huang, HL; Chen, YL; Yang, CY; Wu, MH; Hsieh, CL; Hsiao, W; Peng, YH; Wu, JS; Lin, LM; Sun, M; Chao, YS; Shih, C; Wu, SY; Pan, SL; Hung, MS; Ueng, SH Phenyl Benzenesulfonylhydrazides Exhibit Selective Indoleamine 2,3-Dioxygenase Inhibition with Potent in Vivo Pharmacodynamic Activity and Antitumor Efficacy. J Med Chem59:419-30 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Indoleamine 2,3-dioxygenase 1 |
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| Name: | Indoleamine 2,3-dioxygenase 1 |
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| Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 45330.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14902 |
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| Residue: | 403 |
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| Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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| BDBM50145162 |
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| n/a |
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| Name | BDBM50145162 |
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| Synonyms: | CHEMBL3764508 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12BrN3O3S |
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| Mol. Mass. | 394.243 |
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| SMILES | Brc1ccc(NNS(=O)(=O)c2ccc3[nH]c(=O)ccc3c2)cc1 |
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| Structure | 
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