| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Indoleamine 2,3-dioxygenase 1 |
|---|
| Ligand | BDBM50145168 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1553783 (CHEMBL3766998) |
|---|
| IC50 | 35±n/a nM |
|---|
| Citation |  Lin, SY; Yeh, TK; Kuo, CC; Song, JS; Cheng, MF; Liao, FY; Chao, MW; Huang, HL; Chen, YL; Yang, CY; Wu, MH; Hsieh, CL; Hsiao, W; Peng, YH; Wu, JS; Lin, LM; Sun, M; Chao, YS; Shih, C; Wu, SY; Pan, SL; Hung, MS; Ueng, SH Phenyl Benzenesulfonylhydrazides Exhibit Selective Indoleamine 2,3-Dioxygenase Inhibition with Potent in Vivo Pharmacodynamic Activity and Antitumor Efficacy. J Med Chem59:419-30 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Indoleamine 2,3-dioxygenase 1 |
|---|
| Name: | Indoleamine 2,3-dioxygenase 1 |
|---|
| Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 45330.80 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P14902 |
|---|
| Residue: | 403 |
|---|
| Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
|
|
|
|---|
| BDBM50145168 |
|---|
| n/a |
|---|
| Name | BDBM50145168 |
|---|
| Synonyms: | CHEMBL3764319 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H16BrN3O3S |
|---|
| Mol. Mass. | 410.286 |
|---|
| SMILES | CC(=O)N1CCc2cc(ccc12)S(=O)(=O)NNc1ccc(Br)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
