Reaction Details |
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Target | Platelet-activating factor receptor |
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Ligand | BDBM50145198 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1555330 (CHEMBL3769214) |
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Ki | 2000±n/a nM |
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Citation | Layton, ME; Reif, AJ; Hartingh, TJ; Rodzinak, K; Dudkin, V; Wang, C; Arrington, K; Kelly, MJ; Garbaccio, RM; O'Brien, JA; Magliaro, BC; Uslaner, JM; Huszar, SL; Fillgrove, KL; Tang, C; Kuo, Y; Jacobson, MA Discovery of 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis. Bioorg Med Chem Lett26:1260-4 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Platelet-activating factor receptor |
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Name: | Platelet-activating factor receptor |
Synonyms: | PAF Platelet activating factor | PAF-R | PAFR | PTAFR | PTAFR_HUMAN | Platelet activating factor receptor | Platelet-activating factor receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 39219.60 |
Organism: | Homo sapiens (Human) |
Description: | PAF Platelet activating factor PTAFR HUMAN::P25105 |
Residue: | 342 |
Sequence: | MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLT
MADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVT
RPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKG
SVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAV
FIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF
RKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
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BDBM50145198 |
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n/a |
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Name | BDBM50145198 |
Synonyms: | CHEMBL3765778 |
Type | Small organic molecule |
Emp. Form. | C22H29N3O2 |
Mol. Mass. | 367.4846 |
SMILES | Cc1ccc(cc1-c1ccc2n(CC(C)(C)C)c(=O)n(C)c2n1)C(C)(C)O |
Structure |
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