| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2A |
|---|
| Ligand | BDBM50145627 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1556023 (CHEMBL3767882) |
|---|
| Ki | 0.012600±n/a nM |
|---|
| Citation |  Fiorino, F; Ciano, A; Magli, E; Severino, B; Corvino, A; Perissutti, E; Frecentese, F; Di Vaio, P; Izzo, AA; Capasso, R; Massarelli, P; Nencini, C; Rossi, I; Kedzierska, E; Orzelska-Gòrka, J; Bielenica, A; Santagada, V; Caliendo, G Synthesis, in vitro and in vivo pharmacological evaluation of serotoninergic ligands containing an isonicotinic nucleus. Eur J Med Chem110:133-50 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5-hydroxytryptamine receptor 2A |
|---|
| Name: | 5-hydroxytryptamine receptor 2A |
|---|
| Synonyms: | 5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 52852.05 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | Rat cortex membranes 5-HT2A receptors. |
|---|
| Residue: | 471 |
|---|
| Sequence: | MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGY
LPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYK
SSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
|
|
|
|---|
| BDBM50145627 |
|---|
| n/a |
|---|
| Name | BDBM50145627 |
|---|
| Synonyms: | CHEMBL3763812 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H21FN4O |
|---|
| Mol. Mass. | 328.3839 |
|---|
| SMILES | Fc1ccccc1N1CCN(CCNC(=O)c2ccncc2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
