| Reaction Details |
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 | Report a problem with these data |
| Target | Androgen receptor |
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| Ligand | BDBM50145862 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1553953 (CHEMBL3767965) |
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| Ki | 0.680000±n/a nM |
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| Citation |  Saeed, A; Vaught, GM; Gavardinas, K; Matthews, D; Green, JE; Losada, PG; Bullock, HA; Calvert, NA; Patel, NJ; Sweetana, SA; Krishnan, V; Henck, JW; Luz, JG; Wang, Y; Jadhav, P 2-Chloro-4-[[(1R,2R)-2-hydroxy-2-methyl-cyclopentyl]amino]-3-methyl-benzonitrile: A Transdermal Selective Androgen Receptor Modulator (SARM) for Muscle Atrophy. J Med Chem59:750-5 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Androgen receptor |
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| Name: | Androgen receptor |
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| Synonyms: | ANDR_HUMAN | AR | Androgen Receptor | Androgen receptor (AR) | Androgen receptor/Baculoviral IAP repeat-containing protein 2 | DHTR | Dihydrotestosterone receptor | NR3C4 | Nuclear receptor subfamily 3 group C member 4 |
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| Type: | Receptor |
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| Mol. Mass.: | 99185.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | CHO cells were stably transfected with human AR gene.
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| Residue: | 920 |
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| Sequence: | MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQ
QQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQ
SALECHPERGCVPEPGAAVAASKGLPQQLPAPPDEDDSAAPSTLSLLGPTFPGLSSCSAD
LKDILSEASTMQLLQQQQQEAVSEGSSSGRAREASGAPTSSKDNYLGGTSTISDNAKELC
KAVSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGVPPAVRPTPCAPLAECKGSLLDDSAG
KSTEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLELPSTLSLYKSGALDEAAAYQ
SRDYYNFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAA
GPGSGSPSAAASSSWHTLFTAEEGQLYGPCGGGGGGGGGGGGGGGGGGGGGGGEAGAVAP
YGYTRPPQGLAGQESDFTAPDVWYPGGMVSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRL
ETARDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRN
DCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTSPTEETTQKL
TVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWA
KALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSR
MYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELD
RIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEII
SVQVPKILSGKVKPIYFHTQ
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| BDBM50145862 |
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| n/a |
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| Name | BDBM50145862 |
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| Synonyms: | CHEMBL3765171 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H17ClN2O |
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| Mol. Mass. | 264.751 |
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| SMILES | Cc1c(N[C@@H]2CCC[C@]2(C)O)ccc(C#N)c1Cl |r| |
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| Structure | 
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