| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol lipase-alpha |
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| Ligand | BDBM50147616 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1553309 |
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| IC50 | 100.0±n/a nM |
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| Citation |  Chupak, LS; Zheng, X; Hu, S; Huang, Y; Ding, M; Lewis, MA; Westphal, RS; Blat, Y; McClure, A; Gentles, RG Structure activity relationship studies on chemically non-reactive glycine sulfonamide inhibitors of diacylglycerol lipase. Bioorg Med Chem24:1455-68 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol lipase-alpha |
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| Name: | Diacylglycerol lipase-alpha |
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| Synonyms: | C11orf11 | DAGLA | DGLA_HUMAN | KIAA0659 | NSDDR | Sn1-specific diacylglycerol lipase alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 114947.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1449471 |
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| Residue: | 1042 |
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| Sequence: | MPGIVVFRRRWSVGSDDLVLPAIFLFLLHTTWFVILSVVLFGLVYNPHEACSLNLVDHGR
GYLGILLSCMIAEMAIIWLSMRGGILYTEPRDSMQYVLYVRLAILVIEFIYAIVGIVWLT
QYYTSCNDLTAKNVTLGMVVCNWVVILSVCITVLCVFDPTGRTFVKLRATKRRQRNLRTY
NLRHRLEEGQATSWSRRLKVFLCCTRTKDSQSDAYSEIAYLFAEFFRDLDIVPSDIIAGL
VLLRQRQRAKRNAVLDEANNDILAFLSGMPVTRNTKYLDLKNSQEMLRYKEVCYYMLFAL
AAYGWPMYLMRKPACGLCQLARSCSCCLCPARPRFAPGVTIEEDNCCGCNAIAIRRHFLD
ENMTAVDIVYTSCHDAVYETPFYVAVDHDKKKVVISIRGTLSPKDALTDLTGDAERLPVE
GHHGTWLGHKGMVLSAEYIKKKLEQEMVLSQAFGRDLGRGTKHYGLIVVGHSLGAGTAAI
LSFLLRPQYPTLKCFAYSPPGGLLSEDAMEYSKEFVTAVVLGKDLVPRIGLSQLEGFRRQ
LLDVLQRSTKPKWRIIVGATKCIPKSELPEEVEVTTLASTRLWTHPSDLTIALSASTPLY
PPGRIIHVVHNHPAEQCCCCEQEEPTYFAIWGDNKAFNEVIISPAMLHEHLPYVVMEGLN
KVLENYNKGKTALLSAAKVMVSPTEVDLTPELIFQQQPLPTGPPMPTGLALELPTADHRN
SSVRSKSQSEMSLEGFSEGRLLSPVVAAAARQDPVELLLLSTQERLAAELQARRAPLATM
ESLSDTESLYSFDSRRSSGFRSIRGSPSLHAVLERDEGHLFYIDPAIPEENPSLSSRTEL
LAADSLSKHSQDTQPLEAALGSGGVTPERPPSAAANDEEEEVGGGGGGPASRGELALHNG
RLGDSPSPQVLEFAEFIDSLFNLDSKSSSFQDLYCMVVPESPTSDYAEGPKSPSQQEILL
RAQFEPNLVPKPPRLFAGSADPSSGISLSPSFPLSSSGELMDLTPTGLSSQECLAADKIR
TSTPTGHGASPAKQDELVISAR
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| BDBM50147616 |
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| n/a |
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| Name | BDBM50147616 |
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| Synonyms: | CHEMBL3765497 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H19Cl2F2NO5S |
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| Mol. Mass. | 530.368 |
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| SMILES | C[C@@H](N(CC(O)=O)S(=O)(=O)c1ccc(OC(F)F)cc1)c1ccc(cc1)-c1ccc(Cl)cc1Cl |r| |
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| Structure | 
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