Reaction Details |
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Target | Diacylglycerol lipase-alpha |
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Ligand | BDBM24567 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1553497 (CHEMBL3768668) |
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IC50 | 20±n/a nM |
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Citation | Chupak, LS; Zheng, X; Hu, S; Huang, Y; Ding, M; Lewis, MA; Westphal, RS; Blat, Y; McClure, A; Gentles, RG Structure activity relationship studies on chemically non-reactive glycine sulfonamide inhibitors of diacylglycerol lipase. Bioorg Med Chem24:1455-68 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Diacylglycerol lipase-alpha |
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Name: | Diacylglycerol lipase-alpha |
Synonyms: | DGL-alpha | DGLA_MOUSE | Dagla | Kiaa0659 | Neural stem cell-derived dendrite regulator | Nsddr | Sn1-specific diacylglycerol lipase alpha |
Type: | PROTEIN |
Mol. Mass.: | 115371.22 |
Organism: | Mus musculus |
Description: | ChEMBL_101098 |
Residue: | 1044 |
Sequence: | MPGIVVFRRRWSVGSDDLVLPAIFLFLLHTTWFVILSVVLFGLVYNPHEACSLNLVDHGR
GYLGILLSCMIAEMAIIWLSMRGGILYTEPRDSMQYVLYVRLAILVIEFIYAIVGIVWLT
QYYTSCNDLTAKNVTLGMVVCNWVVILSVCITVLCVFDPTGRTFVKLRATKRRQRNLRTY
NLRHRLEEGQATSWSRRLKVFLCCTRTKDSQSDAYSEIAYLFAEFFRDLDIVPSDIIAGL
VLLRQRQRAKRNAVLDEANNDILAFLSGMPVTRNTKYLDLKNSHEMLRYKEVCYYMLFAL
AAYGWPMYLMRKPTCGLCQLARSCSCCLCPARPRFAPGVTIEEDNCCGCNAIAIRRHFLD
ENMTAVDIVYTSCHDAVYETPFYVAVDHDKKKVVISIRGTLSPKDALTDLTGDAERLPVE
GHRGTWLGHKGMVLSAEYIKKKLEQEMVLSQAFGRDLGRGTKHYGLIVVGHSLGAGTAAI
LSFLLRPQYPTLKCFAYSPPGGLLSEDAMEYSKEFVTAVVLGKDLVPRIGLSQLEGFRRQ
LLDVLQRSTKPKWRIIVGATKCIPKSELPEDQVEVTTLASTRLWTHPSDLTIALSASTPL
YPPGRIIHVVHNHPAEQCCCCEQEEPTYFAIWGDNKAFNEVIISPAMLHEHLPYVVMEGL
NKVLENYNKGKTALLSAAKVMVSPTEVDLTPELIFQQQPLPTGPPLPTGLALELPATEHR
NSSVRSKSQSEMSLEGFSEGRLLSPVAAASAARQDPVELLLLSTQERLAAELQSRRAPLA
TMESLSDTESLYSFDSRRSSGFRSIRGSPSLHAVLERDEGHLFYIDPAIPEENPSLSSRT
ELLAADSLSKHSQDTQPLEAALGSGGVTPERPPSATIEEEEAAGGSEGGGVAPRGELALH
NGRLGDSPSPQVLEFAEFIDSLFNLDSKSSSFQDLYCMMVPESPTSDYTEGPKSPSQQEI
LLRAQFEPNLVPKPPRLFAGSAEPSSGISLSPSFPLSSSGELMDLTPTGLSSQECLATDK
IRTSTPTGHGASPTKQDDLVISAR
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BDBM24567 |
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n/a |
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Name | BDBM24567 |
Synonyms: | (2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl (2S)-2-formamido-4-methylpentanoate | CHEMBL175247 | Orlistat | THLP | Tetrahydrolipstatin | US9328123, Orlistat | Xenical |
Type | Small organic molecule |
Emp. Form. | C29H53NO5 |
Mol. Mass. | 495.7348 |
SMILES | CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r| |
Structure |
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