| Reaction Details |
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 | Report a problem with these data |
| Target | Pantothenate synthetase |
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| Ligand | BDBM50147696 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1555395 (CHEMBL3766329) |
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| IC50 | 1230±n/a nM |
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| Citation |  Samala, G; Devi, PB; Saxena, S; Meda, N; Yogeeswari, P; Sriram, D Design, synthesis and biological evaluation of imidazo[2,1-b]thiazole and benzo[d]imidazo[2,1-b]thiazole derivatives as Mycobacterium tuberculosis pantothenate synthetase inhibitors. Bioorg Med Chem24:1298-307 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pantothenate synthetase |
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| Name: | Pantothenate synthetase |
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| Synonyms: | Chain A, Crystal Structure Of A Pantothenate Synthetase, Apo Enzyme In C2 Space Group | PANC_MYCTU | Pantothenate synthetase | panC |
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| Type: | n/a |
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| Mol. Mass.: | 32675.10 |
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| Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
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| Description: | ChEMBL_102878 |
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| Residue: | 309 |
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| Sequence: | MTIPAFHPGELNVYSAPGDVADVSRALRLTGRRVMLVPTMGALHEGHLALVRAAKRVPGS
VVVVSIFVNPMQFGAGEDLDAYPRTPDDDLAQLRAEGVEIAFTPTTAAMYPDGLRTTVQP
GPLAAELEGGPRPTHFAGVLTVVLKLLQIVRPDRVFFGEKDYQQLVLIRQLVADFNLDVA
VVGVPTVREADGLAMSSRNRYLDPAQRAAAVALSAALTAAAHAATAGAQAALDAARAVLD
AAPGVAVDYLELRDIGLGPMPLNGSGRLLVAARLGTTRLLDNIAIEIGTFAGTDRPDGYR
AILESHWRN
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| BDBM50147696 |
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| n/a |
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| Name | BDBM50147696 |
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| Synonyms: | CHEMBL3763438 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16N4O3S |
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| Mol. Mass. | 392.431 |
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| SMILES | Cc1nc2sccn2c1C(=O)NNC(=O)c1ccc(Oc2ccccc2)cc1 |
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| Structure | 
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