Reaction Details |
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Target | Polyunsaturated fatty acid lipoxygenase ALOX15B |
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Ligand | BDBM56150 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1556335 (CHEMBL3766394) |
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IC50 | >50000±n/a nM |
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Citation | Armstrong, MM; Freedman, CJ; Jung, JE; Zheng, Y; Kalyanaraman, C; Jacobson, MP; Simeonov, A; Maloney, DJ; van Leyen, K; Jadhav, A; Holman, TR A potent and selective inhibitor targeting human and murine 12/15-LOX. Bioorg Med Chem24:1183-90 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Polyunsaturated fatty acid lipoxygenase ALOX15B |
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Name: | Polyunsaturated fatty acid lipoxygenase ALOX15B |
Synonyms: | 15-LOX-2 | 15-Lipo-oxygenase type 2 (15-LOX-2) | 15-Lipoxygenase-2 (15-LOX-2) | 15-lipoxygenase 2 | ALOX15B | Arachidonate 15-lipoxygenase type II | Arachidonate 15-lipoxygenase, type II | Arachidonate 15-lipoxygenase-2 | Epithelial 15-lipoxygenase-2 | LX15B_HUMAN |
Type: | Protein |
Mol. Mass.: | 75850.40 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 676 |
Sequence: | MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPED
VGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGGHLLFPCYQWLEGAGTLVLQE
GTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYSTAK
NANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAFFAS
QFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTSLQAELEKGSLFLVDHGILSGIQT
NVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLSQTPGPNSPIFLPTDDKWDWLLAKTWV
RNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFKLLIPHTRYTLHINTLARELL
IVPGQVVDRSTGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDIPGYYYRDDGMQI
WGAVERFVSEIIGIYYPSDESVQDDRELQAWVREIFSKGFLNQESSGIPSSLETREALVQ
YVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCEGFIATLPPVNAT
CDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQISRGIQERNQGLVL
PYTYLDPPLIENSVSI
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BDBM56150 |
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n/a |
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Name | BDBM56150 |
Synonyms: | (6E)-4-methyl-6-[5-(2-methylphenyl)-1,2-dihydropyrazol-3-ylidene]-1-cyclohexa-2,4-dienone | (6E)-4-methyl-6-[5-(2-methylphenyl)-1,2-dihydropyrazol-3-ylidene]cyclohexa-2,4-dien-1-one | (6E)-4-methyl-6-[5-(o-tolyl)-3-pyrazolin-3-ylidene]cyclohexa-2,4-dien-1-one | 4-methyl-2-[5-(2-methylphenyl)-1H-pyrazol-3-yl]phenol | MLS000099089 | SMR000070479 | cid_5405417 |
Type | Small organic molecule |
Emp. Form. | C17H16N2O |
Mol. Mass. | 264.3217 |
SMILES | Cc1ccc(O)c(c1)-c1cc([nH]n1)-c1ccccc1C |
Structure |
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