Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50148259 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1553559 (CHEMBL3769091) |
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Ki | >1000±n/a nM |
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Citation | Adamska, A; Kluczyk, A; Cerlesi, MC; Calo, G; Janecka, A; Borics, A Synthesis, biological evaluation and structural analysis of novel peripherally active morphiceptin analogs. Bioorg Med Chem24:1582-8 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | Cytochrome P450 3A4 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor | Delta-type opioid receptor (DOR) | OPIATE Delta | OPRD_RAT | Opiate Delta 1 | Opioid receptor | Opioid receptor A | Opioid receptors; mu & delta | Oprd1 | Ror-a | Voltage-gated potassium channel |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40465.04 |
Organism: | Rattus norvegicus (rat) |
Description: | Competition binding assays were using CHO-K1 cell membranes expressing the opioid receptor. |
Residue: | 372 |
Sequence: | MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTAC
TPSDGPGGGAAA
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BDBM50148259 |
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n/a |
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Name | BDBM50148259 |
Synonyms: | CHEMBL3765406 |
Type | Small organic molecule |
Emp. Form. | C28H31F4N5O5 |
Mol. Mass. | 593.5699 |
SMILES | N[C@@H](Cc1ccc(O)cc1)C(=O)N1CC(F)(F)C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CC(F)(F)C[C@@H]1C(N)=O |r| |
Structure |
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