Reaction Details |
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Target | Serine/threonine-protein kinase PAK 1 |
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Ligand | BDBM50148930 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1557608 (CHEMBL3772525) |
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Ki | 6.0±n/a nM |
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Citation | Ndubaku, CO; Crawford, JJ; Drobnick, J; Aliagas, I; Campbell, D; Dong, P; Dornan, LM; Duron, S; Epler, J; Gazzard, L; Heise, CE; Hoeflich, KP; Jakubiak, D; La, H; Lee, W; Lin, B; Lyssikatos, JP; Maksimoska, J; Marmorstein, R; Murray, LJ; O'Brien, T; Oh, A; Ramaswamy, S; Wang, W; Zhao, X; Zhong, Y; Blackwood, E; Rudolph, J Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety. ACS Med Chem Lett6:1241-6 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase PAK 1 |
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Name: | Serine/threonine-protein kinase PAK 1 |
Synonyms: | 2.7.11.1 | Alpha-PAK | Cell division control protein 42 homolog | PAK 1/CDC42 | PAK-1 | PAK1 | PAK1_HUMAN | Serine/threonine-protein kinase PAK 1/PAK 2/PAK 3 | p21-activated kinase 1 | p65-PAK |
Type: | n/a |
Mol. Mass.: | 60640.15 |
Organism: | Homo sapiens (Human) |
Description: | Q13153 |
Residue: | 545 |
Sequence: | MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILP
GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKN
PQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDD
DDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTE
KQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQ
MNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC
MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK
RSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNG
TPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEA
TKNNH
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BDBM50148930 |
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n/a |
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Name | BDBM50148930 |
Synonyms: | CHEMBL3769748 |
Type | Small organic molecule |
Emp. Form. | C26H28ClN7O |
Mol. Mass. | 490 |
SMILES | CCNc1ncc2cc(-c3ccc(cc3Cl)-c3cncc(C)n3)c(=O)n(CC3CCNCC3)c2n1 |
Structure |
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