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TargetSolute carrier family 13 member 5
LigandBDBM50149289
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1557732
IC50 200±n/a nM
Citation Huard KGosset JRMontgomery JIGilbert AHayward MMMagee TVCabral SUccello DPBahnck KBrown JPurkal JGorgoglione MLanba AFutatsugi KHerr MGenung NEAspnes GPolivkova JGarcia-Irizarry CNLi QCanterbury DNiosi MVera NBLi ZKhunte BSiderewicz JRolph TErion DM Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family. J Med Chem 59:1165-75 (2016) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Solute carrier family 13 member 5
Name:Solute carrier family 13 member 5
Synonyms:NACT | Na(+)/citrate cotransporter | NaCT | SLC13A5 | Sodium-coupled citrate transporter | Sodium-dependent citrate transporter | Solute carrier family 13 member 5
Type:PROTEIN
Mol. Mass.:63069.06
Organism:Homo sapiens (Human)
Description:ChEMBL_116736
Residue:568
Sequence:
MASALSYVSKFKSFVILFVTPLLLLPLVILMPAKFVRCAYVIILMAIYWCTEVIPLAVTS
LMPVLLFPLFQILDSRQVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAK
PARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQMEATSAATEAGLELVDKGKAKE
LPGSQVIFEGPTLGQQEDQERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNEL
FPDSKDLVNFASWFAFAFPNMLVMLLFAWLWLQFVYMRFNFKKSWGCGLESKKNEKAALK
VLQEEYRKLGPLSFAEINVLICFFLLVILWFSRDPGFMPGWLTVAWVEGETKYVSDATVA
IFVATLLFIVPSQKPKFNFRSQTEEERKTPFYPPPLLDWKVTQEKVPWGIVLLLGGGFAL
AKGSEASGLSVWMGKQMEPLHAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASMS
RSIGLNPLYIMLPCTLSASFAFMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCV
FLAVNTWGRAIFDLDHFPDWANVTHIET
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  Blast E-value cutoff:
BDBM50149289
n/a
NameBDBM50149289
Synonyms:CHEMBL3770497
TypeSmall organic molecule
Emp. Form.C14H19NO6
Mol. Mass.297.3038
SMILESCCOc1ncc(C)cc1CCC(O)(CC(O)=O)C(O)=O
Structure
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