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TargetSphingosine 1-phosphate receptor 1
LigandBDBM50149580
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1558236 (CHEMBL3772233)
EC50 1259±n/a nM
Citation Demont, EHBailey, JMBit, RABrown, JACampbell, CADeeks, NDowell, SJEldred, CGaskin, PGray, JRHaynes, AHirst, DJHolmes, DSKumar, UMorse, MAOsborne, GJRenaux, JFSeal, GASmethurst, CATaylor, SWatson, RWillis, RWitherington, J Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P3)-Sparing S1P1 Agonists Active at Low Oral Doses. J Med Chem59:1003-20 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sphingosine 1-phosphate receptor 1
Name:Sphingosine 1-phosphate receptor 1
Synonyms:CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:Enzyme
Mol. Mass.:42836.02
Organism:Homo sapiens (Human)
Description:P21453
Residue:382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
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  Blast E-value cutoff:
BDBM50149580
n/a
NameBDBM50149580
Synonyms:CHEMBL3769712
TypeSmall organic molecule
Emp. Form.C19H18ClN3O3S
Mol. Mass.403.883
SMILESCC(C)Oc1ccc(cc1Cl)-c1nnc(Nc2ccc(CC(O)=O)cc2)s1
Structure
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