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TargetLysine-specific demethylase 4E
LigandBDBM195612
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1558375 (CHEMBL3772967)
IC50 501±n/a nM
Citation Westaway, SMPreston, AGBarker, MDBrown, FBrown, JACampbell, MChung, CWDrewes, GEagle, RGarton, NGordon, LHaslam, CHayhow, TGHumphreys, PGJoberty, GKatso, RKruidenier, LLeveridge, MPemberton, MRioja, ISeal, GAShipley, TSingh, OSuckling, CJTaylor, JThomas, PWilson, DMLee, KPrinjha, RK Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives. J Med Chem59:1370-87 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lysine-specific demethylase 4E
Name:Lysine-specific demethylase 4E
Synonyms:2-OG-Dependent Histone Demethylase JMJD2E | Histone Lysine Demethylase | Jumonji domain-containing protein 2E (JMJD2E) | KDM4D-like protein | KDM4DL | KDM4E | KDM4E_HUMAN | Lysine-specific demethylase 4D-like | Lysine-specific demethylase 4E | Lysine-specific demethylase 4E (KDM4E)
Type:Enzyme
Mol. Mass.:56815.71
Organism:Homo sapiens (Human)
Description:B2RXH2
Residue:506
Sequence:
MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHQAGLAKVIPPKEWKARQMY
DDIEDILIATPLQQVTSGQGGVFTQYHKKKKAMRVGQYRRLANSKKYQTPPHQNFADLEQ
RYWKSHPGNPPIYGADISGSLFEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKTWYVVPPEHGQHLERLARELFPDISRGCEAFLR
HKVALISPTVLKENGIPFNCMTQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDY
GKMASQCSCGESTVTFSMDPFVRIVQPESYELWKHRQDLAIVEHTEPRVAESQELSNWRD
DIVLRRAALGLRLLPNLTAQCPTQPVSSGHCYNPKGCGTDAVPGSAFQSSAYHTQTQSLT
LGMSARVLLPSTGSWGSGRGRGRGQGQGRGCSRGRGHGCCTRELGTEEPTVQPASKRRLL
MGTRSRAQGHRPQLPLANDLMTNLSL
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  Blast E-value cutoff:
BDBM195612
n/a
NameBDBM195612
Synonyms:GSK467
TypeSmall organic molecule
Emp. Form.C17H13N5O2
Mol. Mass.319.3174
SMILESO=c1[nH]c(Oc2cnn(Cc3ccccc3)c2)nc2cnccc12
Structure
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