Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetdCTP pyrophosphatase 1
LigandBDBM50150044
Substrate/Competitorn/a
Meas. Tech.ChEBML_1558383
IC50 21±n/a nM
Citation Llona-Minguez, SHöglund, AJacques, SAJohansson, LCalderón-Montaño, JMClaesson, MLoseva, OValerie, NCLundbäck, TPiedrafita, JMaga, GCrespan, EMeijer, LBurgos Morón, EBaranczewski, PHagbjörk, ALSvensson, RWiita, EAlmlöf, IVisnes, TJeppsson, FSigmundsson, KJensen, AJArtursson, PJemth, ASStenmark, PWarpman Berglund, UScobie, MHelleday, T Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1. J Med Chem59:1140-8 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
dCTP pyrophosphatase 1
Name:dCTP pyrophosphatase 1
Synonyms:DCTP1_HUMAN | DCTPP1 | Deoxycytidine-triphosphatase 1 | XTP3TPA | dCTP pyrophosphatase 1 | dCTP pyrophosphatase 1 (DCTPP1)
Type:Protein
Mol. Mass.:18673.58
Organism:Homo sapiens (Human)
Description:Q9H773
Residue:170
Sequence:
MSVAGGEIRGDTGGEDTAAPGRFSFSPEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLAL
VGEVGELAELFQWKTDGEPGPQGWSPRERAALQEELSDVLIYLVALAARCRVDLPLAVLS
KMDINRRRYPAHLARSSSRKYTELPHGAISEDQAVGPADIPCDSTGQTST
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50150044
n/a
NameBDBM50150044
Synonyms:CHEMBL3771039
TypeSmall organic molecule
Emp. Form.C15H11Cl2N3O3
Mol. Mass.352.172
SMILESCc1nc2c(c(Cl)c(Cl)cc2n1Cc1ccc(O)cc1)[N+]([O-])=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: