| Reaction Details |
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 | Report a problem with these data |
| Target | dCTP pyrophosphatase 1 |
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| Ligand | BDBM50150113 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1558383 (CHEMBL3772975) |
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| IC50 | 206±n/a nM |
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| Citation |  Llona-Minguez, S; Höglund, A; Jacques, SA; Johansson, L; Calderón-Montaño, JM; Claesson, M; Loseva, O; Valerie, NC; Lundbäck, T; Piedrafita, J; Maga, G; Crespan, E; Meijer, L; Burgos Morón, E; Baranczewski, P; Hagbjörk, AL; Svensson, R; Wiita, E; Almlöf, I; Visnes, T; Jeppsson, F; Sigmundsson, K; Jensen, AJ; Artursson, P; Jemth, AS; Stenmark, P; Warpman Berglund, U; Scobie, M; Helleday, T Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1. J Med Chem59:1140-8 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| dCTP pyrophosphatase 1 |
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| Name: | dCTP pyrophosphatase 1 |
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| Synonyms: | DCTP1_HUMAN | DCTPP1 | Deoxycytidine-triphosphatase 1 | XTP3TPA | dCTP pyrophosphatase 1 | dCTP pyrophosphatase 1 (DCTPP1) |
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| Type: | Protein |
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| Mol. Mass.: | 18673.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9H773 |
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| Residue: | 170 |
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| Sequence: | MSVAGGEIRGDTGGEDTAAPGRFSFSPEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLAL
VGEVGELAELFQWKTDGEPGPQGWSPRERAALQEELSDVLIYLVALAARCRVDLPLAVLS
KMDINRRRYPAHLARSSSRKYTELPHGAISEDQAVGPADIPCDSTGQTST
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| BDBM50150113 |
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| n/a |
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| Name | BDBM50150113 |
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| Synonyms: | CHEMBL3771148 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H11BF3N3O4 |
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| Mol. Mass. | 365.072 |
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| SMILES | OB(O)c1ccc(Cn2c(nc3c(cccc23)[N+]([O-])=O)C(F)(F)F)cc1 |
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| Structure | 
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