Reaction Details |
| Report a problem with these data |
Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4A |
---|
Ligand | BDBM50150122 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1556442 (CHEMBL3772473) |
---|
Ki | 930±n/a nM |
---|
Citation | Li, P; Zheng, H; Zhao, J; Zhang, L; Yao, W; Zhu, H; Beard, JD; Ida, K; Lane, W; Snell, G; Sogabe, S; Heyser, CJ; Snyder, GL; Hendrick, JP; Vanover, KE; Davis, RE; Wennogle, LP Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases. J Med Chem59:1149-64 (2016) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
cAMP-specific 3',5'-cyclic phosphodiesterase 4A |
---|
Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4A |
Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE2 | PDE46 | PDE4A | PDE4A_HUMAN | Phosphodiesterase 4 (PDE4) | Phosphodiesterase 4A | Phosphodiesterase 4A (PDE4) |
Type: | Enzyme |
Mol. Mass.: | 98113.27 |
Organism: | Homo sapiens (Human) |
Description: | P27815 |
Residue: | 886 |
Sequence: | MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQ
PHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGR
SPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTP
FAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDW
CLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEI
PSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTD
QEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYML
TLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGV
SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDM
VLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLE
LYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL
VHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEE
ISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLT
QQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLP
STAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
|
|
|
BDBM50150122 |
---|
n/a |
---|
Name | BDBM50150122 |
Synonyms: | CHEMBL3769754 |
Type | Small organic molecule |
Emp. Form. | C29H25FN6OS |
Mol. Mass. | 524.612 |
SMILES | [H][C@@]12CCC[C@]1([H])N1C(=N2)N(C)C(=O)c2c(Sc3ccccc3)n(Cc3ccc(cc3)-c3cccc(F)n3)nc12 |r,c:9| |
Structure |
|