| Reaction Details |
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 | Report a problem with these data |
| Target | Transcription intermediary factor 1-alpha |
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| Ligand | BDBM50150816 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1560318 (CHEMBL3779310) |
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| IC50 | 220±n/a nM |
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| Citation |  Palmer, WS; Poncet-Montange, G; Liu, G; Petrocchi, A; Reyna, N; Subramanian, G; Theroff, J; Yau, A; Kost-Alimova, M; Bardenhagen, JP; Leo, E; Shepard, HE; Tieu, TN; Shi, X; Zhan, Y; Zhao, S; Barton, MC; Draetta, G; Toniatti, C; Jones, P; Geck Do, M; Andersen, JN Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. J Med Chem59:1440-54 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transcription intermediary factor 1-alpha |
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| Name: | Transcription intermediary factor 1-alpha |
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| Synonyms: | 6.3.2.- | E3 ubiquitin-protein ligase TRIM24 | RING finger protein 82 | RNF82 | RNF82 | TIF1 | TIF1-alpha | TIF1A | TIF1A_HUMAN | TRIM24 | Transcription intermediary factor 1-alpha | Tripartite motif-containing protein 24 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 116839.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107998 |
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| Residue: | 1050 |
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| Sequence: | MEVAVEKAVAAAAAASAAASGGPSAAPSGENEAESRQGPDSERGGEAARLNLLDTCAVCH
QNIQSRAPKLLPCLHSFCQRCLPAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGSSPFAT
QVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECV
EWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKEQLKLYCETCDK
LTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVNQ
NQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVM
HFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNNTIQFHCDPSFWAQNIINL
GSLVIEDKESQPQMPKQNPVVEQNSQPPSGLSSNQLSKFPTQISLAQLRLQHMQQQVMAQ
RQQVQRRPAPVGLPNPRMQGPIQQPSISHQQPPPRLINFQNHSPKPNGPVLPPHPQQLRY
PPNQNIPRQAIKPNPLQMAFLAQQAIKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYD
GKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQS
PNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPI
RIKQENSGPPENYDFPVVIVKQESDEESRPQNANYPRSILTSLLLNSSQSSTSEETVLRS
DAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNGGELLC
CEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKL
TPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYS
KPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEFRNESE
DNKFSDDSDDDFVQPRKKRLKSIEERQLLK
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| BDBM50150816 |
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| n/a |
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| Name | BDBM50150816 |
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| Synonyms: | CHEMBL3775286 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H25N5O5S |
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| Mol. Mass. | 519.572 |
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| SMILES | Cn1cnc(c1)S(=O)(=O)Nc1cc2n(C)c(=O)n(C)c2cc1Oc1cccc(OCc2ccccc2)c1 |
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| Structure | 
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