| Reaction Details |
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 | Report a problem with these data |
| Target | Hypoxia-inducible factor 1-alpha inhibitor |
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| Ligand | BDBM50151392 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1561035 (CHEMBL3776331) |
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| IC50 | >500000±n/a nM |
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| Citation |  Korczynska, M; Le, DD; Younger, N; Gregori-Puigjané, E; Tumber, A; Krojer, T; Velupillai, S; Gileadi, C; Nowak, RP; Iwasa, E; Pollock, SB; Ortiz Torres, I; Oppermann, U; Shoichet, BK; Fujimori, DG Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors. J Med Chem59:1580-98 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hypoxia-inducible factor 1-alpha inhibitor |
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| Name: | Hypoxia-inducible factor 1-alpha inhibitor |
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| Synonyms: | FIH1 | HIF1AN | HIF1N_HUMAN | Hypoxia-inducible factor 1 (FIH) | Hypoxia-inducible factor 1-alpha inhibitor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40278.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NWT6 |
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| Residue: | 349 |
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| Sequence: | MAATAAEAVASGSGEPREEAGALGPAWDESQLRSYSFPTRPIPRLSQSDPRAEELIENEE
PVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYSASTHKFLYYDEKKMANFQNFKPRSNR
EEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNWINKQQGKRGWG
QLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQS
QVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYWWHHIESLLNGGITITVNFWYKGA
PTPKRIEYPLKAHQKVAIMRNIEKMLGEALGNPQEVGPLLNTMIKGRYN
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| BDBM50151392 |
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| n/a |
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| Name | BDBM50151392 |
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| Synonyms: | CHEMBL3775262 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H14N2O5 |
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| Mol. Mass. | 350.3249 |
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| SMILES | OC(=O)c1ccnc(c1)-c1cc(NC(=O)c2ccc(O)cc2)ccc1O |
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| Structure | 
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