| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Hypoxia-inducible factor 1-alpha inhibitor |
|---|
| Ligand | BDBM50151393 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1561035 (CHEMBL3776331) |
|---|
| IC50 | 473000±n/a nM |
|---|
| Citation |  Korczynska, M; Le, DD; Younger, N; Gregori-Puigjané, E; Tumber, A; Krojer, T; Velupillai, S; Gileadi, C; Nowak, RP; Iwasa, E; Pollock, SB; Ortiz Torres, I; Oppermann, U; Shoichet, BK; Fujimori, DG Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors. J Med Chem59:1580-98 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Hypoxia-inducible factor 1-alpha inhibitor |
|---|
| Name: | Hypoxia-inducible factor 1-alpha inhibitor |
|---|
| Synonyms: | FIH1 | HIF1AN | HIF1N_HUMAN | Hypoxia-inducible factor 1 (FIH) | Hypoxia-inducible factor 1-alpha inhibitor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 40278.92 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NWT6 |
|---|
| Residue: | 349 |
|---|
| Sequence: | MAATAAEAVASGSGEPREEAGALGPAWDESQLRSYSFPTRPIPRLSQSDPRAEELIENEE
PVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYSASTHKFLYYDEKKMANFQNFKPRSNR
EEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNWINKQQGKRGWG
QLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQS
QVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYWWHHIESLLNGGITITVNFWYKGA
PTPKRIEYPLKAHQKVAIMRNIEKMLGEALGNPQEVGPLLNTMIKGRYN
|
|
|
|---|
| BDBM50151393 |
|---|
| n/a |
|---|
| Name | BDBM50151393 |
|---|
| Synonyms: | CHEMBL3775867 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H13N3O5 |
|---|
| Mol. Mass. | 339.3022 |
|---|
| SMILES | Cc1cc(no1)C(=O)Nc1ccc(O)c(c1)-c1cc(ccn1)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
