| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lysine-specific demethylase 4D |
|---|
| Ligand | BDBM50151397 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1561042 (CHEMBL3776338) |
|---|
| IC50 | 11000±n/a nM |
|---|
| Citation |  Korczynska, M; Le, DD; Younger, N; Gregori-Puigjané, E; Tumber, A; Krojer, T; Velupillai, S; Gileadi, C; Nowak, RP; Iwasa, E; Pollock, SB; Ortiz Torres, I; Oppermann, U; Shoichet, BK; Fujimori, DG Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors. J Med Chem59:1580-98 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lysine-specific demethylase 4D |
|---|
| Name: | Lysine-specific demethylase 4D |
|---|
| Synonyms: | JHDM3D | JHDM3D | JMJD2D | JmjC domain-containing histone demethylation protein 3D | Jumonji domain-containing protein 2D | KDM4D | KDM4D_HUMAN | Lysine-specific demethylase 4D |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 58627.79 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_102441 |
|---|
| Residue: | 523 |
|---|
| Sequence: | METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKAR
ETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFED
LERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYL
YFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGA
FLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRW
IDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQDRAVVDHMEPRVPASQELST
QKEVQLPRRAALGLRQLPSHWARHSPWPMAARSGTRCHTLVCSSLPRRSAVSGTATQPRA
AAVHSSKKPSSTPSSTPGPSAQIIHPSNGRRGRGRPPQKLRAQELTLQTPAKRPLLAGTT
CTASGPEPEPLPEDGALMDKPVPLSPGLQHPVKASGCSWAPVP
|
|
|
|---|
| BDBM50151397 |
|---|
| n/a |
|---|
| Name | BDBM50151397 |
|---|
| Synonyms: | CHEMBL3775272 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H18N2O5 |
|---|
| Mol. Mass. | 378.378 |
|---|
| SMILES | COc1cccc(CC(=O)Nc2ccc(O)c(c2)-c2cc(ccn2)C(O)=O)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
