| Reaction Details |
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 | Report a problem with these data |
| Target | Histone acetyltransferase KAT2B |
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| Ligand | BDBM50151650 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1561263 (CHEMBL3778083) |
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| IC50 | 300±n/a nM |
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| Citation |  Simon, RP; Robaa, D; Alhalabi, Z; Sippl, W; Jung, M KATching-Up on Small Molecule Modulators of Lysine Acetyltransferases. J Med Chem59:1249-70 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone acetyltransferase KAT2B |
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| Name: | Histone acetyltransferase KAT2B |
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| Synonyms: | Histone acetyltransferase KAT2A/KAT2B | Histone acetyltransferase PCAF | KAT2B | KAT2B_HUMAN | PCAF |
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| Type: | PROTEIN |
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| Mol. Mass.: | 93045.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1502838 |
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| Residue: | 832 |
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| Sequence: | MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAA
AGTAEGPGGGGSARIAVKKAQLRSAPRAKKLEKLGVYSACKAEESCKCNGWKNPNPSPTP
PRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEED
ADTKQVYFYLFKLLRKSILQRGKPVVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPAKE
RQTIVELAKMFLNRINYWHLEAPSQRRLRSPNDDISGYKENYTRWLCYCNVPQFCDSLPR
YETTQVFGRTLLRSVFTVMRRQLLEQARQEKDKLPLEKRTLILTHFPKFLSMLEEEVYSQ
NSPIWDQDFLSASSRTSQLGIQTVINPPPVAGTISYNSTSSSLEQPNAGSSSPACKASSG
LEANPGEKRKMTDSHVLEEAKKPRVMGDIPMELINEVMSTITDPAAMLGPETNFLSAHSA
RDEAARLEERRGVIEFHVVGNSLNQKPNKKILMWLVGLQNVFSHQLPRMPKEYITRLVFD
PKHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKH
DILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYIKDYEGATLMGCELNPRIPYTEFS
VIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKDGVRQIPIESIPGIRETGWKPSGKEKSK
EPRDPDQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNR
YYVSKKLFMADLQRVFTNCKEYNPPESEYYKCANILEKFFFSKIKEAGLIDK
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| BDBM50151650 |
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| n/a |
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| Name | BDBM50151650 |
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| Synonyms: | CHEMBL3775229 |
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| Type | Small organic molecule |
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| Emp. Form. | C116H205N42O45P3S |
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| Mol. Mass. | 3033.11 |
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| SMILES | CNC(=O)C(C)NC(=O)C(CCCNC(N)=N)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(CCC(N)=O)NC(=O)C(NC(=O)C(C)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(NC(=O)CNC(=O)CNC(=O)NC(CCCCNC(=O)CSCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OCC1OC(C(O)C1OP(O)(O)=O)n1cnc2c(N)ncnc12)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(O)=O)C(C)O)C(C)O)C(C)O |
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| Structure | 
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