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TargetGeranylgeranyl Diphosphate Synthase (GGPPS)
LigandBDBM50013156
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1561702
IC50 17000±n/a nM
Citation Wills VSAllen CHolstein SAWiemer DF Potent Triazole Bisphosphonate Inhibitor of Geranylgeranyl Diphosphate Synthase. ACS Med Chem Lett 6:1195-8 (2015) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Geranylgeranyl Diphosphate Synthase (GGPPS)
Name:Geranylgeranyl Diphosphate Synthase (GGPPS)
Synonyms:Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPSase | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase
Type:Homooctamer; transferase
Mol. Mass.:34867.94
Organism:Homo sapiens (Human)
Description:Recombinant human GGPPS was cloned and expressed in E. coli.
Residue:300
Sequence:
MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
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  Blast E-value cutoff:
BDBM50013156
n/a
NameBDBM50013156
Synonyms:CHEMBL3262351
TypeSmall organic molecule
Emp. Form.C14H21N3Na4O6P2
Mol. Mass.481.2396
SMILES[Na+].[Na+].[Na+].[Na+].[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-n1cc(-[#6]-[#6](P([#8-])([#8-])=O)P([#8-])([#8-])=O)nn1
Structure
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