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TargetCannabinoid receptor 2
LigandBDBM50152111
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1565150 (CHEMBL3782508)
IC50 51±n/a nM
Citation Deiana, VGómez-Cañas, MPazos, MRFernández-Ruiz, JAsproni, BCichero, EFossa, PMuñoz, EDeligia, FMurineddu, GGarcía-Arencibia, MPinna, GA Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties. Eur J Med Chem112:66-80 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cannabinoid receptor 2
Name:Cannabinoid receptor 2
Synonyms:CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:39690.94
Organism:Homo sapiens (Human)
Description:P34972
Residue:360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILS
SHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTAS
VGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCS
ELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLD
VRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYA
LRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
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BDBM50152111
n/a
NameBDBM50152111
Synonyms:CHEMBL3781178
TypeSmall organic molecule
Emp. Form.C30H29Cl2N3O
Mol. Mass.518.477
SMILESClc1ccc(c(Cl)c1)-n1nc(C(=O)NC23CC4CC(CC(C4)C2)C3)c2Cc3cc(ccc3-c12)C1CC1 |TLB:21:16:23:19.20.22,21:20:23:17.16.15,THB:19:18:15:21.20.22,19:20:17.18.23:15|
Structure
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