Reaction Details |
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Target | Oxidized purine nucleoside triphosphate hydrolase |
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Ligand | BDBM50152140 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1565467 (CHEMBL3782136) |
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IC50 | 22±n/a nM |
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Citation | Petrocchi, A; Leo, E; Reyna, NJ; Hamilton, MM; Shi, X; Parker, CA; Mseeh, F; Bardenhagen, JP; Leonard, P; Cross, JB; Huang, S; Jiang, Y; Cardozo, M; Draetta, G; Marszalek, JR; Toniatti, C; Jones, P; Lewis, RT Identification of potent and selective MTH1 inhibitors. Bioorg Med Chem Lett26:1503-7 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Oxidized purine nucleoside triphosphate hydrolase |
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Name: | Oxidized purine nucleoside triphosphate hydrolase |
Synonyms: | 7,8-dihydro-8-oxoguanine triphosphatase | 8ODP_HUMAN | MTH1 | MutT homolog 1 protein (MTH1) | NUDT1 |
Type: | Protein |
Mol. Mass.: | 22514.81 |
Organism: | Homo sapiens (Human) |
Description: | P36639 |
Residue: | 197 |
Sequence: | MYWSNQITRRLGERVQGFMSGISPQQMGEPEGSWSGKNPGTMGASRLYTLVLVLQPQRVL
LGMKKRGFGAGRWNGFGGKVQEGETIEDGARRELQEESGLTVDALHKVGQIVFEFVGEPE
LMDVHVFCTDSIQGTPVESDEMRPCWFQLDQIPFKDMWPDDSYWFPLLLQKKKFHGYFKF
QGQDTILDYTLREVDTV
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BDBM50152140 |
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n/a |
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Name | BDBM50152140 |
Synonyms: | CHEMBL3781296 |
Type | Small organic molecule |
Emp. Form. | C9H14ClN3O2 |
Mol. Mass. | 231.679 |
SMILES | CC(C)(CO)COc1nc(N)ncc1Cl |
Structure |
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