Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Coagulation factor X | ||
Ligand | BDBM50153057 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_1564072 | ||
Ki | >9000±n/a nM | ||
Citation | Corte, JR; Fang, T; Pinto, DJ; Orwat, MJ; Rendina, AR; Luettgen, JM; Rossi, KA; Wei, A; Ramamurthy, V; Myers, JE; Sheriff, S; Narayanan, R; Harper, TW; Zheng, JJ; Li, YX; Seiffert, DA; Wexler, RR; Quan, ML Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group. Bioorg Med Chem24:2257-72 (2016) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Coagulation factor X | |||
Name: | Coagulation factor X | ||
Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor | ||
Type: | Enzyme | ||
Mol. Mass.: | 54726.60 | ||
Organism: | Homo sapiens (Human) | ||
Description: | n/a | ||
Residue: | 488 | ||
Sequence: |
| ||
BDBM50153057 | |||
n/a | |||
Name | BDBM50153057 | ||
Synonyms: | CHEMBL3780324 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H31N5O2 | ||
Mol. Mass. | 469.578 | ||
SMILES | NC[C@H]1CC[C@@H](CC1)C(=O)N[C@@H](Cc1ccccc1)c1cc(ccn1)-c1ccc2[nH]nc(O)c2c1 |r,wU:2.1,wD:5.8,11.12,(2.94,9.71,;2.94,8.48,;1.61,7.7,;1.62,6.16,;.29,5.39,;-1.05,6.16,;-1.05,7.7,;.28,8.47,;-2.38,5.38,;-2.38,4.15,;-3.72,6.15,;-5.05,5.38,;-6.39,6.15,;-7.72,5.38,;-9.06,6.15,;-10.39,5.37,;-10.39,3.83,;-9.05,3.07,;-7.72,3.84,;-5.05,3.84,;-3.72,3.07,;-3.71,1.53,;-5.05,.76,;-6.38,1.53,;-6.38,3.07,;-2.38,.77,;-2.38,-.77,;-1.03,-1.55,;.3,-.77,;1.76,-1.24,;2.66,.02,;1.76,1.24,;2.14,2.41,;.3,.77,;-1.03,1.55,)| | ||
Structure |