| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific demethylase 4D |
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| Ligand | BDBM50122002 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1562429 (CHEMBL3778165) |
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| IC50 | 1585±n/a nM |
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| Citation |  Westaway, SM; Preston, AG; Barker, MD; Brown, F; Brown, JA; Campbell, M; Chung, CW; Diallo, H; Douault, C; Drewes, G; Eagle, R; Gordon, L; Haslam, C; Hayhow, TG; Humphreys, PG; Joberty, G; Katso, R; Kruidenier, L; Leveridge, M; Liddle, J; Mosley, J; Muelbaier, M; Randle, R; Rioja, I; Rueger, A; Seal, GA; Sheppard, RJ; Singh, O; Taylor, J; Thomas, P; Thomson, D; Wilson, DM; Lee, K; Prinjha, RK Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives. J Med Chem59:1357-69 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific demethylase 4D |
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| Name: | Lysine-specific demethylase 4D |
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| Synonyms: | JHDM3D | JHDM3D | JMJD2D | JmjC domain-containing histone demethylation protein 3D | Jumonji domain-containing protein 2D | KDM4D | KDM4D_HUMAN | Lysine-specific demethylase 4D |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58627.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_102441 |
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| Residue: | 523 |
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| Sequence: | METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKAR
ETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFED
LERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYL
YFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGA
FLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRW
IDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQDRAVVDHMEPRVPASQELST
QKEVQLPRRAALGLRQLPSHWARHSPWPMAARSGTRCHTLVCSSLPRRSAVSGTATQPRA
AAVHSSKKPSSTPSSTPGPSAQIIHPSNGRRGRGRPPQKLRAQELTLQTPAKRPLLAGTT
CTASGPEPEPLPEDGALMDKPVPLSPGLQHPVKASGCSWAPVP
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| BDBM50122002 |
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| n/a |
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| Name | BDBM50122002 |
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| Synonyms: | CHEMBL1383671 |
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| Type | Small organic molecule |
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| Emp. Form. | C6H6N2O2 |
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| Mol. Mass. | 138.124 |
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| SMILES | Nc1cnccc1C(O)=O |
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| Structure | 
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