| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Solute carrier organic anion transporter family member 1B1 |
|---|
| Ligand | BDBM50153319 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1562609 (CHEMBL3779258) |
|---|
| IC50 | 8000±n/a nM |
|---|
| Citation |  Westaway, SM; Preston, AG; Barker, MD; Brown, F; Brown, JA; Campbell, M; Chung, CW; Diallo, H; Douault, C; Drewes, G; Eagle, R; Gordon, L; Haslam, C; Hayhow, TG; Humphreys, PG; Joberty, G; Katso, R; Kruidenier, L; Leveridge, M; Liddle, J; Mosley, J; Muelbaier, M; Randle, R; Rioja, I; Rueger, A; Seal, GA; Sheppard, RJ; Singh, O; Taylor, J; Thomas, P; Thomson, D; Wilson, DM; Lee, K; Prinjha, RK Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives. J Med Chem59:1357-69 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Solute carrier organic anion transporter family member 1B1 |
|---|
| Name: | Solute carrier organic anion transporter family member 1B1 |
|---|
| Synonyms: | LST1 | OATP1B1 | OATP2 | OATPC | SLC21A6 | SLCO1B1 | SO1B1_HUMAN | Solute carrier organic anion transporter family member 1B1 | Solute carrier organic anion transporter family member 1B1 (OATP1B1) | Thromboxane B2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 76468.06 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9Y6L6 |
|---|
| Residue: | 691 |
|---|
| Sequence: | MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFE
ISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGY
YRYSKETNINSSENSTSTLSTCLINQILSLNRASPEIVGKGCLKESGSYMWIYVFMGNML
RGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYV
DLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQTPNKPQKERKASLSLHVLE
TNDEKDQTANLTNQGKNITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVF
KYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLS
FYLLYFFILCENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGIT
YISPCLAGCKSSSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAI
QVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCI
KWSTNNCGTRGSCRTYNSTSFSRVYLGLSSMLRVSSLVLYIILIYAMKKKYQEKDINASE
NGSVMDEANLESLNKNKHFVPSAGADSETHC
|
|
|
|---|
| BDBM50153319 |
|---|
| n/a |
|---|
| Name | BDBM50153319 |
|---|
| Synonyms: | CHEMBL3775889 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H12N2O2S |
|---|
| Mol. Mass. | 248.301 |
|---|
| SMILES | Cc1ccsc1CNc1cnccc1C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
