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TargetNuclear receptor ROR-gamma
LigandBDBM50153645
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1561096 (CHEMBL3776820)
EC50 2500±n/a nM
Citation Hirata, KKotoku, MSeki, NMaeba, TMaeda, KHirashima, SSakai, TObika, SHori, AHase, YYamaguchi, TKatsuda, YHata, TMiyagawa, NArita, KNomura, YAsahina, KAratsu, YKamada, MAdachi, TNoguchi, MDoi, SCrowe, PBradley, ESteensma, RTao, HFenn, MBabine, RLi, XThacher, SHashimoto, HShiozaki, M SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR¿ Inhibitor. ACS Med Chem Lett7:23-7 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Nuclear receptor ROR-gamma
Name:Nuclear receptor ROR-gamma
Synonyms:NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:Enzyme Catalytic Domain
Mol. Mass.:58218.40
Organism:Homo sapiens (Human)
Description:P51449
Residue:518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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  Blast E-value cutoff:
BDBM50153645
n/a
NameBDBM50153645
Synonyms:CHEMBL3774888
TypeSmall organic molecule
Emp. Form.C25H26N4O
Mol. Mass.398.5001
SMILESCCn1c(CCC(=O)Nc2cccc3ccccc23)nnc1CCc1ccccc1
Structure
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