| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 2 |
|---|
| Ligand | BDBM50154342 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1560174 (CHEMBL3778245) |
|---|
| IC50 | 60±n/a nM |
|---|
| Citation |  Mariano, M; Hartmann, RW; Engel, M Systematic diversification of benzylidene heterocycles yields novel inhibitor scaffolds selective for Dyrk1A, Clk1 and CK2. Eur J Med Chem112:209-16 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity tyrosine-phosphorylation-regulated kinase 2 |
|---|
| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 2 |
|---|
| Synonyms: | DYRK2 | DYRK2_HUMAN | Dual-specificity tyrosine-phosphorylation regulated kinase 2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 66690.69 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1508025 |
|---|
| Residue: | 601 |
|---|
| Sequence: | MLTRKPSAAAPAAYPTGRGGDSAVRQLQASPGLGAGATRSGVGTGPPSPIALPPLRASNA
AAAAHTIGGSKHTMNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLP
VVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPE
IYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAY
DHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMT
FELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQG
RSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYP
LLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGG
RSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLP
KPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLV
S
|
|
|
|---|
| BDBM50154342 |
|---|
| n/a |
|---|
| Name | BDBM50154342 |
|---|
| Synonyms: | CHEMBL3774448 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H8N2OS2 |
|---|
| Mol. Mass. | 272.345 |
|---|
| SMILES | O=C1NC(=S)S\C1=C/c1ccc2ncccc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
