Reaction Details | |||
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Target | Cyclin-dependent kinase 5 | ||
Ligand | BDBM50154920 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1561740 (CHEMBL3777412) | ||
IC50 | 179±n/a nM | ||
Citation | Vymetalová, L; Havlícek, L; ?turc, A; Skrá?ková, Z; Jorda, R; Pospí?il, T; Strnad, M; Kry?tof, V 5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases. Eur J Med Chem110:291-301 (2016) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Cyclin-dependent kinase 5 | |||
Name: | Cyclin-dependent kinase 5 | ||
Synonyms: | CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit | ||
Type: | Enzyme Subunit | ||
Mol. Mass.: | 33308.61 | ||
Organism: | Homo sapiens (Human) | ||
Description: | n/a | ||
Residue: | 292 | ||
Sequence: |
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BDBM50154920 | |||
n/a | |||
Name | BDBM50154920 | ||
Synonyms: | CHEMBL3774503 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H32N8 | ||
Mol. Mass. | 456.5859 | ||
SMILES | CC(C)c1n[nH]c2c(NCc3ccc(cc3)-c3ccccn3)nc(N[C@H]3CC[C@H](N)CC3)nc12 |r,wU:25.26,wD:28.30,(3.45,2.95,;2.24,2.7,;1.42,3.61,;1.76,1.24,;2.66,.02,;1.76,-1.24,;.3,-.77,;-1.03,-1.55,;-1.02,-3.09,;-2.35,-3.87,;-2.35,-5.41,;-3.68,-6.19,;-3.67,-7.73,;-2.33,-8.49,;-1,-7.71,;-1.01,-6.17,;-2.32,-10.03,;-3.65,-10.81,;-3.64,-12.35,;-2.3,-13.11,;-.97,-12.33,;-.98,-10.79,;-2.38,-.77,;-2.38,.77,;-3.72,1.53,;-5.05,.74,;-5.03,-.8,;-6.36,-1.58,;-7.7,-.82,;-8.76,-1.45,;-7.71,.72,;-6.39,1.5,;-1.03,1.55,;.3,.77,)| | ||
Structure |