| Reaction Details |
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 | Report a problem with these data |
| Target | REST corepressor 1 [4-485] |
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| Ligand | BDBM50155581 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1564915 (CHEMBL3782872) |
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| IC50 | 230±n/a nM |
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| Citation |  Vianello, P; Botrugno, OA; Cappa, A; Dal Zuffo, R; Dessanti, P; Mai, A; Marrocco, B; Mattevi, A; Meroni, G; Minucci, S; Stazi, G; Thaler, F; Trifiró, P; Valente, S; Villa, M; Varasi, M; Mercurio, C Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent. J Med Chem59:1501-17 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| REST corepressor 1 [4-485] |
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| Name: | REST corepressor 1 [4-485] |
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| Synonyms: | KIAA0071 | Protein CoREST | RCOR | RCOR1 | RCOR1_HUMAN | REST corepressor 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53029.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_108118 |
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| Residue: | 482 |
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| Sequence: | MVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAA
APNNGQNKSLAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDPAKL
ARRSQERDNLGMLVWSPNQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLA
DLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKT
SVMDRHARKQKREREESEDELEEANGNNPIDIEVDQNKESKKEVPPTETVPQVKKEKHST
QAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALK
EKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNF
FVNYRRRFNIDEVLQEWEAEHGKEETNGPSNQKPVKSPDNSIKMPEEEDEAPVLDVRYAS
AS
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| BDBM50155581 |
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| n/a |
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| Name | BDBM50155581 |
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| Synonyms: | CHEMBL3781124 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H28Cl2N4O |
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| Mol. Mass. | 423.379 |
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| SMILES | Cl.Cl.CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1ccc(cc1)[C@H]1C[C@@H]1N |r| |
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| Structure | 
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