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TargetREST corepressor 1 [4-485]
LigandBDBM50155770
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1564915 (CHEMBL3782872)
IC50 75±n/a nM
Citation Vianello, PBotrugno, OACappa, ADal Zuffo, RDessanti, PMai, AMarrocco, BMattevi, AMeroni, GMinucci, SStazi, GThaler, FTrifiró, PValente, SVilla, MVarasi, MMercurio, C Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent. J Med Chem59:1501-17 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
REST corepressor 1 [4-485]
Name:REST corepressor 1 [4-485]
Synonyms:KIAA0071 | Protein CoREST | RCOR | RCOR1 | RCOR1_HUMAN | REST corepressor 1
Type:PROTEIN
Mol. Mass.:53029.95
Organism:Homo sapiens (Human)
Description:ChEMBL_108118
Residue:482
Sequence:
MVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAA
APNNGQNKSLAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDPAKL
ARRSQERDNLGMLVWSPNQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLA
DLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKT
SVMDRHARKQKREREESEDELEEANGNNPIDIEVDQNKESKKEVPPTETVPQVKKEKHST
QAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALK
EKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNF
FVNYRRRFNIDEVLQEWEAEHGKEETNGPSNQKPVKSPDNSIKMPEEEDEAPVLDVRYAS
AS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50155770
n/a
NameBDBM50155770
Synonyms:CHEMBL3781885
TypeSmall organic molecule
Emp. Form.C28H31ClN4O4
Mol. Mass.523.023
SMILESCl.N[C@@H]1C[C@H]1c1ccc(NC(=O)c2ccc(NC(=O)OCc3ccccc3)c(c2)N2CCOCC2)cc1 |r|
Structure
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