Reaction Details |
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Target | REST corepressor 1 [4-485] |
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Ligand | BDBM50155770 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1564915 (CHEMBL3782872) |
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IC50 | 75±n/a nM |
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Citation | Vianello, P; Botrugno, OA; Cappa, A; Dal Zuffo, R; Dessanti, P; Mai, A; Marrocco, B; Mattevi, A; Meroni, G; Minucci, S; Stazi, G; Thaler, F; Trifiró, P; Valente, S; Villa, M; Varasi, M; Mercurio, C Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent. J Med Chem59:1501-17 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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REST corepressor 1 [4-485] |
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Name: | REST corepressor 1 [4-485] |
Synonyms: | KIAA0071 | Protein CoREST | RCOR | RCOR1 | RCOR1_HUMAN | REST corepressor 1 |
Type: | PROTEIN |
Mol. Mass.: | 53029.95 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_108118 |
Residue: | 482 |
Sequence: | MVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAA
APNNGQNKSLAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDPAKL
ARRSQERDNLGMLVWSPNQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLA
DLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKT
SVMDRHARKQKREREESEDELEEANGNNPIDIEVDQNKESKKEVPPTETVPQVKKEKHST
QAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALK
EKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNF
FVNYRRRFNIDEVLQEWEAEHGKEETNGPSNQKPVKSPDNSIKMPEEEDEAPVLDVRYAS
AS
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BDBM50155770 |
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n/a |
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Name | BDBM50155770 |
Synonyms: | CHEMBL3781885 |
Type | Small organic molecule |
Emp. Form. | C28H31ClN4O4 |
Mol. Mass. | 523.023 |
SMILES | Cl.N[C@@H]1C[C@H]1c1ccc(NC(=O)c2ccc(NC(=O)OCc3ccccc3)c(c2)N2CCOCC2)cc1 |r| |
Structure |
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