Reaction Details | |||
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Target | REST corepressor 1 [4-485] | ||
Ligand | BDBM50155773 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1564915 (CHEMBL3782872) | ||
IC50 | 6.5±n/a nM | ||
Citation | Vianello, P; Botrugno, OA; Cappa, A; Dal Zuffo, R; Dessanti, P; Mai, A; Marrocco, B; Mattevi, A; Meroni, G; Minucci, S; Stazi, G; Thaler, F; Trifiró, P; Valente, S; Villa, M; Varasi, M; Mercurio, C Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent. J Med Chem59:1501-17 (2016) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
REST corepressor 1 [4-485] | |||
Name: | REST corepressor 1 [4-485] | ||
Synonyms: | KIAA0071 | Protein CoREST | RCOR | RCOR1 | RCOR1_HUMAN | REST corepressor 1 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 53029.95 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_108118 | ||
Residue: | 482 | ||
Sequence: |
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BDBM50155773 | |||
n/a | |||
Name | BDBM50155773 | ||
Synonyms: | CHEMBL3781751 | US9469597, 5 | ||
Type | Small organic molecule | ||
Emp. Form. | C15H22N2 | ||
Mol. Mass. | 230.3486 | ||
SMILES | [H][C@@]1(CC[C@H](N)CC1)N[C@@H]1C[C@H]1c1ccccc1 |r,wU:9.9,wD:11.13,4.4,1.0,(-4.65,6.17,;-4.67,5.14,;-4.65,3.62,;-5.99,2.87,;-7.32,3.66,;-8.39,3.05,;-7.3,5.2,;-5.95,5.95,;-3.34,4.36,;-3.36,2.83,;-4.13,1.49,;-2.67,1.54,;-1.33,.77,;,1.54,;1.33,.77,;1.33,-.77,;,-1.54,;-1.33,-.77,)| | ||
Structure |