| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 12 |
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| Ligand | BDBM142597 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1563502 (CHEMBL3783187) |
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| IC50 | 40±n/a nM |
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| Citation |  Onions, ST; Ito, K; Charron, CE; Brown, RJ; Colucci, M; Frickel, F; Hardy, G; Joly, K; King-Underwood, J; Kizawa, Y; Knowles, I; Murray, PJ; Novak, A; Rani, A; Rapeport, G; Smith, A; Strong, P; Taddei, DM; Williams, JG Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma. J Med Chem59:1727-46 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 12 |
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| Name: | Mitogen-activated protein kinase 12 |
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| Synonyms: | ERK6 | MAP kinase p38 gamma | MAPK12 | MK12_HUMAN | Mitogen-activated protein kinase 12 (MAPK12 p38 gamma) | Mitogen-activated protein kinase 12 (p38 gamma) | Mitogen-activated protein kinase 12 Gamma | Mitogen-activated protein kinase p38 gamma (p38 MAPKγ) | SAPK3 | p38 delta/gamma |
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| Type: | Protein |
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| Mol. Mass.: | 41938.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P53778 |
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| Residue: | 367 |
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| Sequence: | MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK
VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV
TAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGAR
VSKETPL
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| BDBM142597 |
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| n/a |
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| Name | BDBM142597 |
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| Synonyms: | US8933228, Ref 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H36N6O4 |
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| Mol. Mass. | 592.6874 |
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| SMILES | COCC(=O)Nc1cc(COc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1 |
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| Structure | 
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