| Reaction Details |
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 | Report a problem with these data |
| Target | Steroid 17-alpha-hydroxylase/17,20 lyase |
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| Ligand | BDBM50391846 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1563728 (CHEMBL3784029) |
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| IC50 | 2.0±n/a nM |
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| Citation |  Huang, A; Jayaraman, L; Fura, A; Vite, GD; Trainor, GL; Gottardis, MM; Spires, TE; Spires, VM; Rizzo, CA; Obermeier, MT; Elzinga, PA; Todderud, G; Fan, Y; Newitt, JA; Beyer, SM; Zhu, Y; Warrack, BM; Goodenough, AK; Tebben, AJ; Doweyko, AM; Gold, DL; Balog, A Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer. ACS Med Chem Lett7:40-5 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Steroid 17-alpha-hydroxylase/17,20 lyase |
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| Name: | Steroid 17-alpha-hydroxylase/17,20 lyase |
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| Synonyms: | 17-alpha-hydroxyprogesterone aldolase | CP17A_MACFA | CYP17 | CYP17A1 | CYPXVII | Cytochrome P450 17A1 | Cytochrome P450-C17 | Cytochrome P450c17 | Steroid 17-alpha-hydroxylase/17,20 lyase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57634.34 |
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| Organism: | Macaca fascicularis |
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| Description: | ChEMBL_116757 |
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| Residue: | 508 |
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| Sequence: | MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY
GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQVTTLDILSNNRKGIAFADYGAH
WQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQTIDISFPVFVAITNVIS
LICFNISYKNGDPELKIVHNYNEGIIDSLGKESLVDLFPWLKVFPNKTLEKLKRHVKTRN
DLLTKIFENYKEKFHSDSITNMLDVLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF
GAGVETTTSVVKWIVAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV
LRIRPVAPMLIPHKANVDSSIGEFAVDKGTHVIINLWALHHNEKEWHQPDQFMPERFLNP
AGTQLISPSLSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGNP
KVVFLIDSFKVKIKVRQAWREAQAEGST
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| BDBM50391846 |
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| n/a |
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| Name | BDBM50391846 |
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| Synonyms: | CHEMBL2147041 | US9133160, 31 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12F3N3 |
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| Mol. Mass. | 291.2711 |
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| SMILES | Cc1ccncc1-c1cccc2n(CC(F)(F)F)cnc12 |
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| Structure | 
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