Ki Summary

Reaction Details

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Target

Steroid 17-alpha-hydroxylase/17,20 lyase

Ligand

BDBM50156282

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1563729 (CHEMBL3784030)

IC50

2.0±n/a nM

Citation

Huang, A; Jayaraman, L; Fura, A; Vite, GD; Trainor, GL; Gottardis, MM; Spires, TE; Spires, VM; Rizzo, CA; Obermeier, MT; Elzinga, PA; Todderud, G; Fan, Y; Newitt, JA; Beyer, SM; Zhu, Y; Warrack, BM; Goodenough, AK; Tebben, AJ; Doweyko, AM; Gold, DL; Balog, A Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer. ACS Med Chem Lett7:40-5 (2016) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Steroid 17-alpha-hydroxylase/17,20 lyase

Name:

Steroid 17-alpha-hydroxylase/17,20 lyase

Synonyms:

Type:

PROTEIN

Mol. Mass.:

57634.34

Organism:

Macaca fascicularis

Description:

ChEMBL_116757

Residue:

508

Sequence:

MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY
GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQVTTLDILSNNRKGIAFADYGAH
WQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQTIDISFPVFVAITNVIS
LICFNISYKNGDPELKIVHNYNEGIIDSLGKESLVDLFPWLKVFPNKTLEKLKRHVKTRN
DLLTKIFENYKEKFHSDSITNMLDVLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF
GAGVETTTSVVKWIVAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV
LRIRPVAPMLIPHKANVDSSIGEFAVDKGTHVIINLWALHHNEKEWHQPDQFMPERFLNP
AGTQLISPSLSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGNP
KVVFLIDSFKVKIKVRQAWREAQAEGST

BDBM50156282

n/a

Name

BDBM50156282

Synonyms:

CHEMBL3780847

Type

Small organic molecule

Emp. Form.

C24H31NO

Mol. Mass.

349.509

SMILES

[H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)C1CC[C@@]1(C)C2CC=C1c1cccnc1 |r,c:22,t:3|

Structure